Archer goes to the Mexican border to find a notorious coyote, "Moreno". When "Moreno" is apparently Mercedes Moreno, a gorgeous woman, Sterling shoots Lana and Cyril (after confirming they were wearing kevlar) and proceeds to help Mercedes and Chewie to continue moving the people they were smuggling, including Lupe. A brush with Border Patrol leaves Sterling to need medical attention from an alcoholic veterinarian. Eventually Mercedes reveals, via a note, that this was all a ruse, and her mother Maria Moreno was the actual coyote.
The title of this episode is a reference to the film "Coyote Ugly."
The scorpion in the foreground at the beginning is a callback to Season 1 Episode 9 of "Sealab 2021," "All That Jazz," wherein Captain Murphy befriends a scorpion (who he names Ben), while trapped under a fallen soda machine. Ben, in turn, was a reference to a movie about a boy befriending a murderous rat.
Archer seems to have learned some Spanish by the time of this episode.
As she tries to come up with a snappy line while capturing the border patrol, Mercedes Moreno echoes Archer's famous line (a recurring joke) "I had something for this," albeit in Spanish.
Moreno means "Brown" in Spanish. The name of Merces' mother, Maria Moreno, may be a reference to Maria Brown, the mother of Stephen F. Austin who inspired him to settle Texas.
Bilbo is alive in this episode. However, Malory slaps him and causes a heart attack and no one helps him (in fact, Doctor Krieger is the only one who notices and seems amused). In "Once Bitten" it was Krieger who criticised her for this. According to production codes, this episode was supposed to be the second in the season, which explains the discontinuity.
When Archer handcuffs Cyril to Lana he says "Just like The Defiant Ones." The Defiant Ones was a movie in which two prisoners, one black (Sidney Poitier) and one white (Tony Curtis), escape while shackled to one another.